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International Journal of Pharmaceutical Research and Development

Vol. 6, Issue 1, Part A (2024)

Stability indicating method development and validation for the determination of piperaquine tetraphosphate and dihydro artemisinin by RP HPLC

Author(s):

Arun Kumar Sah, Paul Richards M and BA Vishwanath

Abstract:

On the basis of experimental results, the proposed method is suitable for the quantitative determination of piperaquine tetraphosphate and dihydro artemisinin in pharmaceutical dosage form. The method provides great sensitivity, adequate linearity and repeatability. The estimation of piperaquine tetraphosphate and dihydro artemisinin was done by RP-HPLC. The Phosphate buffer was pH 3.6 and the mobile phase was optimized which consists of Methanol: Phosphate buffer mixed in the ratio of 70:30% v/ v. A Symmetry C18 (4.6 x 150mm, 5m, Make XTerra) column used as stationary phase. By using UV detector at 273 nm. 

Pages: 38-52  |  78 Views  19 Downloads

How to cite this article:
Arun Kumar Sah, Paul Richards M and BA Vishwanath. Stability indicating method development and validation for the determination of piperaquine tetraphosphate and dihydro artemisinin by RP HPLC. Int. J. Pharm. Res. Dev. 2024;6(1):38-52. DOI: 10.33545/26646862.2024.v6.i1a.42