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International Journal of Pharmaceutical Research and Development

Vol. 3, Issue 1, Part A (2021)

Validated stability indicating RP-HPLC method for simultaneous determination of netupitant and palanosetron in combined pharmaceutical formulations

Author(s):

Nagaraju Pappula, M Lakshmi Sowmya, N Naga Udayasri

Abstract:

A simple stability indicating high performance liquid chromatographic method has been developed for the simultaneous determination of Netupitant and palanosetron using reverse phase Kromasil C18 (4.6 x 150mm, 5µm) with UV detector at 240nm. The mobile phase consisting of ACN, Potassium disodiumhydrogen phosphate in the ratio of 40:60 (v/v) and at a flow rate of 1 mL/min. The method was linear over the concentration range of 75-450μg/m for Netupitat and 0.125-0.75μg/m for palanosetron. The method was validated and was successfully employed for the routine quantitative analysis of pharmaceutical formulations containing Netupitant and Palanosetron in combined tablet dosage form.

Pages: 01-06  |  1318 Views  600 Downloads


International Journal of Pharmaceutical Research and Development
How to cite this article:
Nagaraju Pappula, M Lakshmi Sowmya, N Naga Udayasri. Validated stability indicating RP-HPLC method for simultaneous determination of netupitant and palanosetron in combined pharmaceutical formulations. Int. J. Pharm. Res. Dev. 2021;3(1):01-06. DOI: 10.33545/26646862.2021.v3.i1a.18
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