Vol. 3, Issue 1, Part A (2021)

A simple stability indicating high performance liquid chromatographic method has been developed for the simultaneous determination of Netupitant and palanosetron using reverse phase Kromasil C18 (4.6 x 150mm, 5µm) with UV detector at 240nm. The mobile phase consisting of ACN, Potassium disodiumhydrogen phosphate in the ratio of 40:60 (v/v) and at a flow rate of 1 mL/min. The method was linear over the concentration range of 75-450μg/m for Netupitat and 0.125-0.75μg/m for palanosetron. The method was validated and was successfully employed for the routine quantitative analysis of pharmaceutical formulations containing Netupitant and Palanosetron in combined tablet dosage form.