Vol. 7, Issue 2, Part I (2025)

Pulsatile drug delivery systems (PDDS) represent an innovative approach in controlled drug release, designed to deliver medications at predetermined intervals or in a time-dependent manner. Unlike conventional drug delivery systems, which provide a continuous release, PDDS offer the advantage of releasing drugs in a "pulsatile" manner, closely mimicking the body's natural biological rhythms or therapeutic requirements. This system is particularly useful for drugs that require targeted delivery at specific times or for conditions where a drug's efficacy depends on the timing of its release, such as in circadian rhythm-based diseases, post-surgery care, or for the treatment of diseases like asthma, arthritis, and hypertension. The primary mechanisms employed in PDDS include osmotic pressure, swelling, and enzyme-sensitive materials. These systems are engineered to release phase followed by a 'g in an initial lag please phase. This paper explores the different types of pulsatile of releasing drugs in a "pulsatile" manner, closely mimicking the body's natural biological rhythms or therapeutic requirements. This system is particularly useful for drugs that require targeted delivery at specific times or for conditions where a drug's efficacy depends on the timing of its release, such as in circadian rhythm-based diseases, post-surgery care, or for the treatment of diseases like asthma, arthritis, and hypertension. The primary mechanisms employed in PDDS include osmotic pressure, swelling, and enzyme-sensitive materials. These systems are engineered to release a drug in an initial lag phase followed by a rapid release phase. This paper explores the different types of pulsatile delivery systems, such as time-controlled, stimuli-sensitive, and lag-phase delivery systems, along with their potential applications, benefits, challenges, and recent advancements in the field. By enhancing the temporal control of drug release, PDDS offer a promising solution to improve therapeutic outcomes, minimize side effects, and improve patient compliance.