Vol. 7, Issue 2, Part I (2025)

Epigenetics involves heritable changes in gene expression without altering DNA sequences, significantly influencing development, differentiation, and disease susceptibility. Key mechanisms include DNA methylation, histone modifications, and non-coding RNAs, all crucial for regulating chromatin structure and transcription. Dysregulation relates to various diseases, including cancer and metabolic disorders.Recent advances in epigenetic therapeutics, such as DNA methyltransferase and histone deacetylase inhibitors, indicate the potential for successful cancer treatments. However, challenges like delivery systems and ethical issues persist. Further exploration of epigenetic mechanisms can enhance human health and precision medicine.