Vol. 7, Issue 2, Part F (2025)

Foam-based drug delivery systems represent a significant advancement beyond conventional dosage forms, offering unique physicochemical and therapeutic advantages for dermatological, wound healing, and mucosal drug administration. These systems utilize gas-liquid or gas-solid dispersions to create low-density, highly spreadable formulations that enhance drug penetration, patient comfort, and adherence, particularly in sensitive or inflamed skin conditions and hard-to-reach areas. In dermatology, foam formulations have demonstrated superior therapeutic efficacy, such as a 30% improvement in psoriasis treatment compared to traditional topicals, and are especially beneficial for disorders like eczema due to improved skin coverage and hydration For wound healing, foam dressings often composed of biocompatible polymers and sometimes loaded with antimicrobials or growth factors provide a moist environment, absorb exudate, and facilitate controlled drug release, accelerating tissue regeneration and reducing infection risk. Mucosal delivery benefits from foam’s mucoadhesive properties and rapid drug release, as seen in multi-layered systems that improve peptide permeation and bioavailability. Recent innovations include propellant-free foams, nanotechnology integration, and tailored polymer compositions to optimize stability, drug release, and patient outcomes. Collectively, foam-based systems are poised to transform topical and mucosal therapies by enhancing bioavailability, safety, and patient quality of life.