Vol. 7, Issue 2, Part E (2025)

The study aimed to formulate and evaluate Apalutamide immediate release tablets using various polymers, including Ac-Di-Sol, Sodium Starch Glycolate, and Crospovidone, in different ratios to optimize the drug release profile. Several formulations were prepared, and their pre-compression and post-compression parameters, such as flow properties, hardness, friability, drug content, and dissolution, were thoroughly evaluated to ensure they met the required standards. Among the formulations, Formulation A3 demonstrated the most promising results, achieving a 99.01% drug release within 30 minutes, significantly outperforming other formulations in terms of dissolution rate. All pre- and post-compression parameters of Formulation A3 were found to be within acceptable limits. This formulation proved to be the most optimized in terms of release characteristics and overall quality, suggesting its potential for further development in the treatment of conditions requiring rapid drug onset.