Vol. 7, Issue 2, Part B (2025)

It was Kostanecki and Tambor that gave them the name "chalcones." Chalcones' antibacterial, antifungal, anti-inflammatory, and anticancer qualities have been thoroughly studied in the literature. Several possible pharmacological features, such as enzyme inhibitory activity, anticancer, anti-inflammatory, antibacterial, antifungal, antimalarial, antiprotozoal, and antifilarial activity, were demonstrated by the presence of the reactive α, β-unsaturated system in the chalcone's ring. Adding substituent groups to the aromatic ring can change the structure, boost potency, decrease toxicity, and expand pharmacological activity. Some chalcone compounds were more effective than tetracycline and vancomycin, two common antibiotics. Chalcones have a wide range of biological activity and are an essential component of many natural sources. Two distinct techniques are used to produce chalcone derivatives. Aldol condensation of suitable aromatic ketones or substituted ketones with benzaldehydes or substituted benzaldehydes is used to create the chemicals. Following that, the chemicals were purified by recrystallization or column chromatography. Physical characteristics such as melting point and TLC were used to determine the structure of the synthesized compounds, and then spectroscopic examination such as UV and infrared radiation spectroscopy was performed.