Vol. 7, Issue 1, Part E (2025)

Fast dissolving tablets (FDTs) have emerged as a revolutionary approach in drug delivery systems, offering enhanced patient compliance, especially among pediatric, geriatric, and dysphagic populations. These tablets disintegrate and dissolve rapidly in the saliva without the need for water, providing a convenient and effective alternative to conventional dosage forms. This review article explores the formulation strategies, technologies, and evaluation parameters associated with FDTs. Various techniques such as direct compression, lyophilization, sublimation, and spray drying have been utilized to achieve the desired disintegration time and mechanical strength. The selection of suitable excipients, particularly superdisintegrants and flavoring agents, plays a critical role in ensuring rapid dissolution and patient acceptability. Additionally, this review discusses the regulatory considerations, stability issues, and recent advancements in the field, including the application of nanotechnology and 3D printing. Fast dissolving tablets not only improve the onset of therapeutic action but also enhance bioavailability in some cases, especially for drugs with extensive first-pass metabolism. The article concludes by highlighting future prospects and the growing significance of FDTs in personalized medicine and chronic disease management, reflecting their potential to transform conventional drug delivery paradigms.