Vol. 7, Issue 1, Part B (2025)

A solid dispersion approach has been attempted to create fast-dissolving carbamazepine tablets, employing varying amounts of crosscarmellose sodium as the super disintegrating agent. This medication's poor absorption upon oral administration and extremely low solubility in biological fluids is its main issues. The produced tablets were assessed for drug content, hardness, friability, disintegration time, wetting time, and in vitro dissolution investigations. The mannitol solid dispersion formulations exhibited a disintegration time ranging from 12.83 to 16.79 seconds and a drug release duration ranging from 8 to 10 minutes. Nevertheless, the formulations made with PEG-6000 solid dispersion failed to dissolve within the allotted window of time for tablets that dissolve quickly. Within 8 minutes, SM4 demonstrated 99.50% drug release out of all formulations. DSC and FTIR studies were used to characterize the produced tablets. DSC and FTIR investigations did not confirm any chemical interaction between the medication and excipients. The formulations were determined to be stable in the stability investigation, which was carried out in accordance with ICH criteria. The findings showed that rapidly dissolving carbamazepine tablets, which is a poorly soluble medication, improved bioavailability, enhanced dissolution, effective therapy, and ultimately better patient compliance.