Vol. 7, Issue 1, Part B (2025)

A case of suspected leukocytoclastic vasculitis (LCV) caused by cephalosporins. As a result of taking cephalosporins, the patient experienced the development of typical LCV skin lesions, such as purpura and bullae. A skin biopsy's histopathological analysis, which showed fibrinoid necrosis of small vessels and neutrophilic infiltration, validated the diagnosis. After stopping the suspected cephalosporin, the proper course of treatment was started. The significance of taking drug hypersensitivity—especially to cephalosporins into account when making a differential diagnosis of LCV is demonstrated by this case. Effective management and the avoidance of potential complications related to this uncommon but potentially dangerous adverse drug reaction depend on the prompt identification and cessation of the offending agent.