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International Journal of Pharmaceutical Research and Development

Vol. 7, Issue 1, Part A (2025)

Stability, characterization, and manufacturing optimization of ferrous Ascorbate: A Comprehensive Study by West Bengal Chemical Industries Ltd., Kolkata, India

Author(s):

Poulami Gupta Banerjee, Atanuka Paul, Argha Chakraborty, Abhijit Porel and Pooja Mallick

Abstract:

Ferrous ascorbate, an essential pharmaceutical compound used in the treatment of iron deficiency anemia, exhibits unique physicochemical and solid-state properties that influence its manufacturability and clinical efficacy. This study investigates the stability and characterization of ferrous ascorbate produced by West Bengal Chemical Industries Ltd. Kolkata, India (WBCIL), focusing on preformulation studies, force degradation assessments, and analytical techniques including UV, IR spectroscopy, and HPLC. Key challenges such as hygroscopicity, flow properties, and tablet integrity were addressed through rigorous testing protocols, including flow parameter studies and swelling index evaluations. Comprehensive force degradation studies under various conditions revealed the compound's susceptibility to thermolysis and photolysis while highlighting its stability in acidic, basic, and oxidative environments. Flow properties, UV, and IR characterization studies confirmed alignment with established literature values, ensuring the reproducibility and quality of the compound. These findings underscore the significance of optimizing manufacturing processes and packaging solutions to enhance the stability and efficacy of ferrous ascorbate formulations.

Pages: 32-37  |  101 Views  41 Downloads


International Journal of Pharmaceutical Research and Development
How to cite this article:
Poulami Gupta Banerjee, Atanuka Paul, Argha Chakraborty, Abhijit Porel and Pooja Mallick. Stability, characterization, and manufacturing optimization of ferrous Ascorbate: A Comprehensive Study by West Bengal Chemical Industries Ltd., Kolkata, India. Int. J. Pharm. Res. Dev. 2025;7(1):32-37. DOI: 10.33545/26646862.2025.v7.i1a.91
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