Prashant Purohit and Priyanka Mishra
In the recent days, most of the prevailing diseases and nutritional disorders are treated with natural medicines. Several plant extracts and phyto-constituents, despite having excellent bioactivity in vitro demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or both, resulting in poor absorption and bioavailability. So, much work has been directed towards the development of new concept in herbal delivery system i.e., “Phytosomes” which are better absorbed, utilized and as a result produce better results than conventional herbal extracts. Phytosomes stand sophisticated herbal preparations that contain the phytoactive ingredients found in extracted from herbs and have the ability towards change the cell membranes hydrophilic to lipophilic state. They may be produced as pills, creams, gels, suspensions, and other medicinal forms. Many illnesses now have a fantastic treatment alternative in phytosomes. Their therapeutic applicability may be limited by poor bioavailability and selectivity. The great potential of the emerging nanotechnology in the delivery of bioactive phytochemicals is reviewed, with particular focus on phytosomes as an innovative lipid-based nanocarrier. Additionally, we compared phytosomes with liposomes as the gold standard of lipid-based nanocarriers for the topical delivery of phytochemicals. Finally, the advantages of phytosomes in topical applications are discussed.
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