BS Chandru, Dr. S Daisy Chella Kumari, N Gokula Kannan, K Anusha and MR Dhanesh Kumar
Floating micro-balloons are a novel drug delivery system designed to protect sensitive drugs from gastric acids and enzymes, releasing them in the gastrointestinal tract. Micro-balloons are gastro-retentive drug delivery system based on non-effervescent approach. Micro-balloons (hollow microspheres) are empty spherical particles without a core having a size less than 200 µm. Thus solubility of the drug is increased, which improves bioavailability and decreases drug waste. This system makes better approach for gastric retention, which would decreases variations in plasma drug concentrations. Multiparticulate system of low density particles can efficiently prolong the gastric retention time of drugs. This review provides an overview of micro-balloons, their formulation methods, characterization, marketed formulations and their applications in controlled drug delivery. We discuss the benefits and limitations of micro-balloons and future directions for research and development.
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