Contact: +91-9711224068
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
International Journal of Pharmaceutical Research and Development

Vol. 5, Issue 2, Part A (2023)

An In silico study on the Inhibition of Corona virus disease (COVID-19) Protease by the extract of Indian herbal plants

Author(s):

Ravi Prakash, Raj Kumar and RB Singh

Abstract:

The Corona virus (COVID-19) has quickly spread across the globe and becoming a pandemic. This disease has a variable impact in different countries depending on their cultural norms, mitigation efforts and health infrastructure. In India, a majority of people upon Traditional Indian Medicine to treat human maladies due to less-cost, easier availability and without any side-effect. These medicines are made by herbal plants. This study aims to assess the Indian herbal plants in the pursuit of potential COVID-19 inhibitors using in silico approaches. We have considered 18 extracted compounds of 11 different species of these plants. Our calculated lipophilicity, aqueous solubility and binding affinity of the extracted compounds suggest that the inhibition potentials in the order; harsingar > aloe vera > giloy > turmeric > neem > ashwagandha >ginger>red onion > tulsi> cannabis > black pepper. On comparing the binding affinity with hydroxychloroquine, we note that the inhibition potentials of the extracts of harsingar, aloe vera and giloy are very promising. Therefore, we believe that these findings will open further possibilities and accelerate the works towards finding an antidote for this malady.

Pages: 15-18  |  222 Views  62 Downloads


International Journal of Pharmaceutical Research and Development
How to cite this article:
Ravi Prakash, Raj Kumar and RB Singh. An In silico study on the Inhibition of Corona virus disease (COVID-19) Protease by the extract of Indian herbal plants. Int. J. Pharm. Res. Dev. 2023;5(2):15-18. DOI: 10.33545/26646862.2023.v5.i2a.34
Call for book chapter