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International Journal of Pharmaceutical Research and Development

Vol. 5, Issue 1, Part A (2023)

Formulation and evaluation of immunomodulatory orodispersible herbal granules

Author(s):

UN Dungarwal and Dr. AS Mundada

Abstract:

COVID 19 was declared as a global pandemic by World Health Organization (WHO). The significance of immunity boosters has grown in these demanding circumstances. The objective of the present study is to formulate herbal orodispersible granules by incorporating the extract of lemon peel (Citrus limon) having immunomodulatory activity. Better compliance can be achieved by orodispersible granules to pediatric, geriatric, and bedridden patients. The lemon peel extract was obtained by using the ultrasound-assisted extraction technique. The extract was subjected to preliminary organoleptic characterization for color, odor, solubility, and percent yield. Phytochemical screening was performed on lemon peel extract for the qualitative and quantitative analysis of flavonoids, phenolic compounds, etc. Banana flour was used in different concentrations (1-3%) to formulate various batches of orodispersible granules which act as superdisintegrant. The compatibility study was performed for lemon peel extract with excipients using FTIR and DSC. Herbal granules were prepared by extrusion and spheronization technique and evaluated for angle of repose, bulk density, tapped density, Carr's index, Hausner’s ratio, In vitro disintegration time, and In vitro release characteristics. The total phenolic content of lemon peel extract was found to be 185 mg Gallic acid equivalent/ gm. While total flavonoid content was found to be 170gm Quercetin equivalent/gm of extract. Orodispersible granules of lemon peel extract were formulated. All batches had shown better flow properties. The granules dispersed rapidly in 39 to 87s. Lemon peel extract was successfully formulated and evaluated as herbal granules using banana flour. Results of the present study revealed that developed formulations may serve as herbal products with better quality, consistency, and stability.

Pages: 01-07  |  346 Views  134 Downloads

How to cite this article:
UN Dungarwal and Dr. AS Mundada. Formulation and evaluation of immunomodulatory orodispersible herbal granules. Int. J. Pharm. Res. Dev. 2023;5(1):01-07. DOI: 10.33545/26646862.2023.v5.i1a.28