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International Journal of Pharmaceutical Research and Development

Vol. 3, Issue 1, Part A (2021)

Development of in-vitro in-vivo correlation of optimized fenofibrate tartaric acid co-crystal tablet

Author(s):

Ashwini Madgulkar, Mangesh Bhalekar, Anil Battase, Pravin Waghchaure, Sumedh Pradhan, Dhananjay Pagare

Abstract:

Fenofibrate an antilipidemic drug belonging to BCS class II, has very low oral bioavailability. Many approaches have been reported in literature and we selected a simple approach of formulating co-crystals to enhance the dissolution and subsequently bioavailability of fenofibrate. After reporting conformer screening, preparation and in-vitro evaluation of tartaric acid fenofibrate co-crystals as separate research work, formulation and in-vivo studies were undertaken in this work and an attempt to develop in-vitro in-vivo correlation was made using deconvolution and time scaling approach.

Pages: 07-14  |  1259 Views  537 Downloads

How to cite this article:
Ashwini Madgulkar, Mangesh Bhalekar, Anil Battase, Pravin Waghchaure, Sumedh Pradhan, Dhananjay Pagare. Development of in-vitro in-vivo correlation of optimized fenofibrate tartaric acid co-crystal tablet. Int. J. Pharm. Res. Dev. 2021;3(1):07-14. DOI: 10.33545/26646862.2021.v3.i1a.19