International Journal of Pharmaceutical Research and Development

authors
Ashwini Madgulkar, Mangesh Bhalekar, Anil Battase, Pravin Waghchaure, Sumedh Pradhan, Dhananjay Pagare

abstract
Fenofibrate an antilipidemic drug belonging to BCS class II, has very low oral bioavailability. Many approaches have been reported in literature and we selected a simple approach of formulating co-crystals to enhance the dissolution and subsequently bioavailability of fenofibrate. After reporting conformer screening, preparation and in-vitro evaluation of tartaric acid fenofibrate co-crystals as separate research work, formulation and in-vivo studies were undertaken in this work and an attempt to develop in-vitro in-vivo correlation was made using deconvolution and time scaling approach.