International Journal of Pharmaceutical Research and Development

International Journal of Pharmaceutical Research and Development


International Journal of Pharmaceutical Research and Development
International Journal of Pharmaceutical Research and Development
2021, Vol. 3, Issue 1
Validated stability indicating RP-HPLC method for simultaneous determination of netupitant and palanosetron in combined pharmaceutical formulations

Nagaraju Pappula, M Lakshmi Sowmya, N Naga Udayasri

A simple stability indicating high performance liquid chromatographic method has been developed for the simultaneous determination of Netupitant and palanosetron using reverse phase Kromasil C18 (4.6 x 150mm, 5µm) with UV detector at 240nm. The mobile phase consisting of ACN, Potassium disodiumhydrogen phosphate in the ratio of 40:60 (v/v) and at a flow rate of 1 mL/min. The method was linear over the concentration range of 75-450μg/m for Netupitat and 0.125-0.75μg/m for palanosetron. The method was validated and was successfully employed for the routine quantitative analysis of pharmaceutical formulations containing Netupitant and Palanosetron in combined tablet dosage form.
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How to cite this article:
Nagaraju Pappula, M Lakshmi Sowmya, N Naga Udayasri. Validated stability indicating RP-HPLC method for simultaneous determination of netupitant and palanosetron in combined pharmaceutical formulations. International Journal of Pharmaceutical Research and Development, Volume 3, Issue 1, 2021, Pages 01-06
International Journal of Pharmaceutical Research and Development International Journal of Pharmaceutical Research and Development