Nidhi Malviya, Sarang Kumar Jain
Rabeprazole Sodium buffered Formulation were successively prepared and evaluated by performing the preformulation studies, formulation development and optimization and stability studies. The colour, odour, nature and taste of the drug were evaluated. It was found to be as per the monograph. Rabeprazole sodium was found to be very soluble in water and methanol, freely soluble in ethanol, chloroform and ethyl acetate and insoluble in ether and n- hexane. Drug excipients compatibility study with and without FTIR spectroscopic analysis of drug with excipients showed that the drug was compatible with excipients which were used in the formulation. Rabeprazole buffer tablets were prepared by direct compression method and table in tablet technology. The prepared powder blend was evaluated for parameters like angle of repose, bulk density, tapped density, compressibility index and Hausner ratio. The obtained results indicated that it has good flow property for direct compression method. Tablets formulations were evaluated for hardness, thickness, weight variation, friability, assay and disintegration time. All these parameters were found to be within the pharmacopoieal limits. The drug release was found to be above 99 % within 60 mins when RT6 formulation In vitro dissolution study was performed. The in vitro acid neutralizing capacity of formulations study of all formulation showed good results. The stability studies of RT6 formulation at 40 oC/75% RH for a period of 3months indicated that there was no significant change in description, disintegration time, drug content and in vitro dissolution profiles.
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