Vol. 1, Issue 1, Part A (2019)

In the current investigation, methanolic extract of Coccinia indica was studied for its effect on wound healing, using an excision and incision wound models in rats. The leaves of the plant were extracted with methanol by using soxhlet apparatus. In preliminary wound healing activity, 5% ointment prepared with methanolic extract was evaluated for wound healing potential in excision and incision wound models. Wound contraction studies, Epithelialization period and tensile strength were determined for the assessment of healing potential of plant extract. The results revealed that group treated with methanolic extract shows better wound closure and epithelialization period when compared with control. Thus it was concluded that methanolic extract of Coccinia indica has the significant wound healing activity.